Efficacy and safety of Dynavisc® gel in prevention of scar adhesions recurrence after flexor tendons tenolysis in zone 2. Multicenter retrospective cohort study
Franco Bassetto 1, Giorgio Pajardi 2, Bruno Battiston 3, Massimo Corain 4, Silvia Sargenti 5, Carlotta Scarpa 1, Chiara Novelli 2, Cesare Tiengo 1, Andrea Vitali 6, Federico Facchin 1,7, Maddalena Bertolini 3, Luciano Cara 8, Giancarlo Caruso 6
1 Plastic and Reconstructive Surgery Unit, Department of Neurosciences, University of Padova, Padua, ltaly
2 Department of Clinical Sciences and Community Healtb, The University of Milan, Milan, ltaly
3 Department of Orthopedics and Traumatology, Orthopedic and Trauma Center, AOU Citn della Salute e della Scienza, Turin, ltaly
4 Department of Hand Surgery and Microsurgery, University Hospital of Verona, Verona, Italy
5 Complex organizational structure of functional rebabilitation, Palagi Hospital(l. 0.T,), Azienda USL Toscana Centro, Florence, ltaly
6 6 Hand Surgery Unit, Palagi Hospital (1.0.T,), Azienda Usl Toscana Centro, Florence, ltaly
7 Plastic Surgery Unit, Azienda UISS 8 Berica, San Bortolo Hospital, Vicenza, ltaly
8 Ortbopedics and Reconstructive Microsurgery Unit, Cagliari, Italy
Ann. Ital. Chir. 2023, 94(5), 529–536
Published: 1 Sep 2023
Abstract
AIM: Dynavisc® is a novel surgical product made of carboxymethylcellulose (CMC) and Polyethylene Oxide (PEO) designed to reduce post-surgical adhesions in tendons surgery. A multicenter retrospective cohort study was performed to investigate the clinical safety and efficacy of the Dynavisc® gel in reducing post-surgical adhesions after flexor tenolysis in zone 2. MATERIAL OF STUDY: Thirty-one patients suffering from stiff finger after flexor tendon repairs in zone 2 treated with standard release with (18 Dynavisc®-treated group) or without (13 controls) anti-adhesion gel application into the flexor tendon sheath and around the site of the tenolysis, were collected in five different hand surgery units. Safety profile and functional outcomes (based on TAM test and the The Quick-DASH questionnaire) were examined from patients’ charts and analyzed. RESULTS: The application of Dynavisc® posed no safety concerns and it was not related to any additional complication. CONCLUSIONS:This clinical study confirm the safety of Dynavisc® gel application in hand surgery demonstrating its poten-tial long-term benefits after flexor tendon tenolysis.
