Efficacy and safety of Dynavisc® gel in prevention of scar adhesions recurrence after flexor tendons tenolysis in zone 2. Multicenter retrospective cohort study

Franco  Bassetto; Giorgio  Pajardi; Bruno  Battiston; Massimo  Corain; Silvia  Sargenti; Carlotta  Scarpa; Chiara  Novelli; Cesare  Tiengo; Andrea  Vitali; Federico  Facchin; Maddalena  Bertolini; Luciano  Cara; Giancarlo  Caruso

1 Sep 2023Article

Franco Bassetto ¹Giorgio Pajardi ²Bruno Battiston ³Massimo Corain ⁴Silvia Sargenti ⁴Carlotta Scarpa ¹Chiara Novelli ²Cesare Tiengo ¹Andrea Vitali ⁵Federico Facchin ⁶Maddalena Bertolini ³Luciano Cara ⁷Giancarlo Caruso ⁵

Affiliations

Article Info

¹ Plastic and Reconstructive Surgery Unit, Department of Neurosciences, University of Padova, Padua, Italy

² Department of Clinical Sciences and Community Health, The University of Milan, Milan, Italy

³ Department of Orthopedics and Traumatology, Orthopedic and Trauma Center, AOU Città della Salute e della Scienza, Turin, Italy

⁴ Department of Hand Surgery and Microsurgery, University Hospital of Verona, Verona, Italy

⁵ Hand Surgery Unit, Palagi Hospital (I.O.T.), Azienda Usl Toscana Centro, Florence, Italy

⁶ Plastic Surgery Unit, Azienda ULSS 8 Berica, San Bortolo Hospital, Vicenza, Italy;Plastic and Reconstructive Surgery Unit, Department of Neurosciences, University of Padova, Padua, Italy

⁷ Orthopedics and Reconstructive Microsurgery Unit, Cagliari, Italy

Abstract

AIM: Dynavisc® is a novel surgical product made of carboxymethylcellulose (CMC) and Polyethylene Oxide (PEO) designed to reduce post-surgical adhesions in tendons surgery. A multicenter retrospective cohort study was performed to investigate the clinical safety and efficacy of the Dynavisc® gel in reducing post-surgical adhesions after flexor tenolysis in zone 2. MATERIAL OF STUDY: Thirty-one patients suffering from stiff finger after flexor tendon repairs in zone 2 treated with standard release with (18 Dynavisc®-treated group) or without (13 controls) anti-adhesion gel application into the flexor tendon sheath and around the site of the tenolysis, were collected in five different hand surgery units. Safety profile and functional outcomes (based on TAM test and the The Quick-DASH questionnaire) were examined from patients’ charts and analyzed. RESULTS: The application of Dynavisc® posed no safety concerns and it was not related to any additional complication. CONCLUSIONS:This clinical study confirm the safety of Dynavisc® gel application in hand surgery demonstrating its poten-tial long-term benefits after flexor tendon tenolysis.

Keywords

Flexor Tendon Repair
Tendon Adhesions
Tenolysis