Managing non-healing wounds is nowadays a challenging issue because of costly burden for each national health care system and the important disability of patients in terms of increased pain and decreased overall quality of life. Chronic skin lesions are usually stucked in the inflammatory phase of reparative cycle and defined from absence of a clinical improvement in a temporal span ranging from four weeks to three months. Improvement of wound microenviroment can play a leading role in the enhancement of chronic ulcers’ healing process, as well as the standard care application on the basis of etiopathogenesis of ulcer. Hereafter, we will focus on the interesting use of blue light therapy as therapeutical option on wound microenviroment, in order to unblock repair process and promote healing in stubborn wounds.