OBJECTIVE: To evaluate the effect of OASIS preloaded punctal plug versus Smart Plug punctal plug Retrospectively registered in the treatment of aqueous-deficient dry eye. METHODS: 47 patients were randomly divided into a control group and an experimental group. The control group was treated with Smart Plug punctal plug treatment, and the experimental group was treated with OASIS preloaded punctal plug treatment. The ocular surface disease index (OSDI) questionnaire score, Schirmer I test and break-up time (BUT) results before and after treatment, and the incidences of postoperative complications were compared between the two groups. RESULTS: This study showed that compared with before treatment, the OSDI scores of patients were significantly improved at six months after treatment in both the experimental group and control group. After treatment, there was no significant difference in OSDI score, Schirmer I test, and BUT level between the two groups. In addition, the Smart Plug punctal plug treatment group had a significant improvement in BUT at three months after operation compared with before treatment. CONCLUSION: The OASIS preloaded punctal plug and the Smart Plug punctal plug can significantly improve dry eye symptoms. Furthermore, the OASIS preloaded punctal plug can facilitate intraoperative procedures, and the abnormal implantation due to the expansion of the embolic volume can be reduced.