1 Jan 2022Article
Relationships between androgen receptor expression and clinicopathological parameters in male breast cancer
Ramazan Uçak 1Canan Tanik 1Cemal Kaya 2Emre Bozkurt 2Fevziye Kabukçuoğlu 1
Affiliations
Article Info
1 Department of Pathology; University of Health Sciences Sisli Hamidiye Etfal Education and Research Hospital, İstanbul, Turkey
2 Department of General Surgery; University of Health Sciences Sisli Hamidiye Etfal Education and Research Hospital, İstanbul, Turkey
Ann. Ital. Chir., 2022, 93(1), 40-47;
Published: 1 Jan 2022
Copyright © 2022 Annali Italiani di Chirurgia
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
INTRODUCTION: Most patients with male breast cancer (MBC) express the androgen receptor (AR). AR expression in these tumors may have both prognostic and predictive values because its presence indicates the potential benefits of an anti-androgen therapeutic approach. The present study aimed to investigate the relationship between AR expression and clinicopathological parameters in MBC. MATERIAL AND METHODS: The data of 35 patients who received a histological diagnosis of MBC at the pathology department of our hospital between January 2007 and December 2017 were retrospectively reviewed. The patientsħ demographic data, follow-up records and pathology reports were recorded. AR expression status and its relationship with clinicopathological parameters were evaluated. The chi-square test was used to compare independent groups. Univariate survival analyses were performed using the Kaplan–Meier survival procedure. A p value of ≤0.05 was considered statistically significant. RESULTS: There was no significant relationship between AR expression and AJCC stage (p=0.585), pathologic stage (p=0.696), histologic grade (p=0.685), lymph-node status (p=0.685), survival rate (p=1.000), age(p=1.000), lymphovascular invasion (p=0.700), perineural invasion(p=1.000), skin invasion (p=1.000), nipple involvement(p=1.000), DCIS presence(p=1.000), ER positivity(p=1.000), PR positivity (p=0.218), Her2 expression (p=0.523), Ki67 index (p=0.685), Luminal A group (p=0.700), Luminal B group (p=0.691), triple negative group (p=1.000). CONCLUSION: Further investigation of the relation between AR expression and clinicopathological parameters of patients with MBC might yield important information and lead to the development of additional treatment options.
Keywords
- Androgen receptor
- AR expression
- breast cancer
- Male Breast cancer
- Prognosis
- Receptor status