Propofol: a safe anaesthetic drug in experimental cardiac surgery in rabbits
Enrico Giuliani 1, Antonio Manenti 2, Alberto Barbieri 1, Alberto Farinetti 2, Anna Vittoria Mattioli 2
Affiliations
Article Info
1 Department of Medical and Surgical Sciences University of Modena and Reggio Emilia, Italy
2 Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine University of Modena and Reggio Emilia, Italy
Abstract
ACKGROUND: Experimental surgery needs a pharmacological approach that can interfere with cardiac function. CASE REPORT: In a animal model of regenerative medicine of myocardium we use an anaesthesiological protocol that included Propofol, a benzodiazepine (Midazolam) and an alpha-2 adrenergic agent. RESULTS: In a group of 15 rabbits undergoing cardiac surgery we reported 1 arrhythmic complication during stem cell injection. DISCUSSION: The functional cardio- respiratory depressor activity of Propofol was compensated by alpha-2 adrenergic drugs, avoiding serious complications. We hypothesize that the functional cardio-respiratory depressor of different anaes- thesiological drugs can be reversed by the contemporary administration of with adrenergic agents.
Keywords
- Arrhythmias
- Cardiac ischemia
- Cardiovascular toxicity
- Propofol