1 Jan 2018Case Report
Propofol: a safe anaesthetic drug in experimental cardiac surgery in rabbits
Enrico Giuliani 1Antonio Manenti 2Alberto Barbieri 1Alberto Farinetti 2Anna Mattioli 2
Affiliations
Article Info
1 University of Modena and Reggio Emilia, Italy; Department of Medical and Surgical Sciences
2 University of Modena and Reggio Emilia, Italy; Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine
Ann. Ital. Chir., 2018, 89(1), 92-94;
Published: 1 Jan 2018
Copyright © 2018 Annali Italiani di Chirurgia
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
ACKGROUND: Experimental surgery needs a pharmacological approach that can interfere with cardiac function. CASE REPORT: In a animal model of regenerative medicine of myocardium we use an anaesthesiological protocol that included Propofol, a benzodiazepine (Midazolam) and an alpha-2 adrenergic agent. RESULTS: In a group of 15 rabbits undergoing cardiac surgery we reported 1 arrhythmic complication during stem cell injection. DISCUSSION: The functional cardio- respiratory depressor activity of Propofol was compensated by alpha-2 adrenergic drugs, avoiding serious complications. We hypothesize that the functional cardio-respiratory depressor of different anaes- thesiological drugs can be reversed by the contemporary administration of with adrenergic agents.
Keywords
- Arrhythmias
- Cardiac ischemia
- Cardiovascular toxicity
- Propofol