1 Jan 2017Article
Serum vascular endothelial growth factor receptor-3 levels in patients with esophageal squamous cell cancer
Aziz Sümer 1Ali Demir 1Ahu Kemik 2Alpaslan Yavuz 3Burak Suvak 4Ahmet Dülger 4Sevim Purisa 5Ozgur Kemik 1
Affiliations
Article Info
1 Department of General Surgery, Yuzuncu Yıl University Medical Faculty, Van, Turkey
2 Department of Biochemistry, Faculty of Medicine, Istanbul University, Istanbul, Turkey
3 Department of Radiology, Yuzuncu Yıl University Medical Faculty, Van, Turkey
4 Department of Gastroenterology, Yuzuncu Yıl University Medical Faculty, Van, Turkey
5 Department of Biostatistics, Faculty of Medicine, Istanbul University, Istanbul, Turkey
Ann. Ital. Chir., 2017, 88(1), 20-25;
Published: 1 Jan 2017
Copyright © 2017 Annali Italiani di Chirurgia
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
AIM: Esophageal cancer is one of the most aggressive tumors of the gastrointestinal tract. In this study, we quantified the serum vascular endothelial growth factor-3 (VEGFR-3) expression in patients with esophageal squamous cell carcinoma (ESCC) to evaluate the role of VEGFR-3 in ESCC. MATERIALS AND METHODS: Ninety five patients with ESCC were studied. Pre-therapy and preoperative samples were stored and ELISA was used to designate the concentrations of VEGFR-3. RESULTS: The serum values of VEGFR-3 were significantly higher in patients with ESCC than in healthy donors (p<0.0001). CONCLUSIONS: The results imply a very good sensitivity of VEGFR-3 in ESCC. VEGFR-3 may be a good diagnostic biomarker for ESCC.
Keywords
- Biomarker
- ESCC
- VEGFR-3
