Serum vascular endothelial growth factor receptor-3 levels in patients with esophageal squamous cell cancer
Aziz Sümer 1, Ali Demir 1, Ahu Sarbay Kemik 2, Alpaslan Yavuz 3, Burak Suvak 4, Ahmet Cumhur Dülger 4, Sevim Purisa 5, Ozgur Kemik 1
Affiliations
Article Info
1 Department of General Surgery, Yuzuncu Yıl University Medical Faculty, Van, Turkey
2 Department of Biochemistry, Faculty of Medicine, Istanbul University, Istanbul, Turkey
3 Department of Radiology, Yuzuncu Yıl University Medical Faculty, Van, Turkey
4 Department of Gastroenterology, Yuzuncu Yıl University Medical Faculty, Van, Turkey
5 Department of Biostatistics, Faculty of Medicine, Istanbul University, Istanbul, Turkey
Abstract
AIM: Esophageal cancer is one of the most aggressive tumors of the gastrointestinal tract. In this study, we quantified the serum vascular endothelial growth factor-3 (VEGFR-3) expression in patients with esophageal squamous cell carcinoma (ESCC) to evaluate the role of VEGFR-3 in ESCC. MATERIALS AND METHODS: Ninety five patients with ESCC were studied. Pre-therapy and preoperative samples were stored and ELISA was used to designate the concentrations of VEGFR-3. RESULTS: The serum values of VEGFR-3 were significantly higher in patients with ESCC than in healthy donors (p<0.0001). CONCLUSIONS: The results imply a very good sensitivity of VEGFR-3 in ESCC. VEGFR-3 may be a good diagnostic biomarker for ESCC.
Keywords
- Biomarker
- ESCC
- VEGFR-3