AIM: The purpose of this study was to determine if there are different outcomes between the right and left laparoscopic adrenalectomy according to our experience. MATERIAL OF STUDY: From September 2010 to September 2015 forty-two LA were performed. Variables compared include age, body mass index (BMI), ASA score, operative time, estimated blood loss, conversions, gland size, tumor size, postoperative ambulation, postoperative hospitalization, perioperative and postoperative complications. RESULTS: Substantially there are no difference in postoperative results between right and left LA. DISCUSSION: We report difference in the operative time because left procedure is more complex. The difference in the blood loss due to two intraoperative bleeding in right side, can be considered a given accidental. CONCLUSIONS: It’s important an adequate learning curve to improve intraoperative and therefore postoperative Outcomes.