AIM: Lip cancer is the most common malignant tumour of the oral cavity and the oral commissure is the origin of the tumour in 6% to 8.5% of cases. Reconstruction of oral commissure defects aims at securing oral competence and providing an acceptable appearance. Satisfactory reconstruction of defects affecting the lip commissure is always challenging. MATERIAL OF STUDY: The authors present a selected group of 22 patients, who, between November 2005 and 31st October 2012, underwent reconstruction for primary or secondary defects involving the oral commissure. RESULTS: The results were generally satisfactory, both functionally and cosmetically. The patients had been followed up for 5 years. CONCLUSIONS: All patients had excellent oral competence during rest, speaking and eating. Good sphinteric function was obtained in early postoperative days. No drooling or air leakage. The aesthetic results were good in all patients.