Is lymph node ratio prognostic factor for survival in elderly patients with node positive breast cancer? The Anatolian Society of Medical Oncology
Ali Inal 1, Tulay Akman 2, Sebnem Yaman 3, Selcuk Cemil Ozturk 4, Caglayan Geredeli 5, Mehmet Bilici 6, Mevlude Inanc 7, Hakan Harputoglu 8, Umut Demirci 9, Ali Suner 10, Havva Yesil Cınkır 11, Suleyman Alıcı 12, Dilsen Colak 13, Ozlem Uysal Sonmez 14, Gamze Goksel 15, Gamze Gokoz Dogu 16, Huseyin Engin 17, Olcun Umit Unal 2, Tulay Tamozlu 3, Suleyman Buyukberber 4, Cem Melih Boruban 5, Abdurrahman Isıkdogan 1
1 Dicle University, Department of Medical Oncology, Diyarbakir, Turkey
2 Dokuz Eylül University, Department of Medical Oncology, izmir, Turkey
3 Department of Medical Oncology, Ankara Numune Education and Research Hospital, Ankara, Turkey
4 Gazi University, Department of Medical Oncology, Ankara, Turkey
5 Secuk University, Meram Medical Faculty, Konya, Turkey
6 Ataturk University, Department of Medical Oncology, Erzurum, Turkey
7 Erciyes University, Department of Medical Oncology, Kayseri, Turkey
8 Inonu University, Department of Medical Oncology, Malatya, Turkey
9 Ataturk Education and Research Hospital, Ankara, Turkey
10 Gaziantep University, Department of Medical Oncology, Gaziantep, Turkey
11 Dr. Abdurrahman Yurtaslan Education and Research Hospital, 2. Department of Medical Oncology, Ankara, Turkey
12 Goztepe Medikal Park Hospital, stanbul, Turkey
13 Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey
14 Dr. Abdurrahman Yurtaslan Education and Research Hospital, 1. Department of Medical Oncology, Ankara, Turkey
15 Celal Bayar University, Department of Medical Oncology, Manisa, Turkey
16 Pamukkale University School of Medicine, Department of Medical Oncology, denizli, Turkey
17 Zonguldak Karaelmas University School of Medicine, Department of Medical Oncology, Zonguldak
Ann. Ital. Chir. 2013, 84(2), 143–148
Published: 1 Mar 2013
Abstract
Several studies have now demonstrated that the lymph node ratio (LNR), as a superior indicator of axillary tumor burden to the number of excised nodes. While, about the prognostic value of LNR on the the survival of elderly patients is limited. The aim of this retrospective multicenter study is to evaluate the prognostic value of lymph node ratio in elderly patients with node positive breast cancer. METHODS: Onehundredeightyfour patient with operable breast cancer, recruited from 17 institutions, were enrolled into the retrospectively study. Eleven potential prognostic variables were chosen for analysis in this study. Univariate and multivariate analyses were conducted to identify prognostic factors associated with survival. RESULT: Among the eleven variables of univariate analysis, four variables were identified to have prognostic significance for Overall survival (OS): pathologic tumor size (T), No. of positive nodes (N), LNR and estrogen receptor-positive (ER). Among the eleven variables of univariate analysis, two variables were identified to have prognostic significance for Disease-free survival (DFS): N and LNR. Multivariate analysis by Cox proportional hazard model showed that T, LNR and ER were considered independent prognostic factors for OS. Furthermore, LNR was considered independent prognostic factors for DFS. CONCLUSION: In conclusion, the LNR was associated with the prognostic importance for DFS and OS in elderly patients who were administered adjuvant treatments.
