BACKGROUND: Multiple gliomas, although a rare finding, can present with a clinical and radiological picture similar to that of metastatic disease, abscesses, lymphoma and demyelination. CASE REPORT: We report a rare case of multiple gliomas located in the left cerebral hemisphere, with a complex presentation emulating other possible differential diagnoses. CONCLUSION: Multiple gliomas should be taken into consideration as part of the differential diagnosis of multiple parenchymal brain lesions. Certain imaging modalities and findings can be extremely valuable with obtaining a diagnosis, and the subsequent formulation of a therapeutic strategy.