When acute cholecystitis is suspected in a very high-risk patient, percutaneous cholecystostomy should be considered as a safe and effective temporary management of patients with gallstones. Whenever possible, percutaneous cholecystostomy should be followed by laparoscopic cholecystectomy. In elderly patients who are inappropriate surgical candidates because of severe concomitant systemic diseases, less invasive treatments may prevent recurrence. Our experience shows the feasibility of percutaneous cholecystostomy to achieve an effective treatment of acute cholecystitis in surgical high-risk patients with a physiologic biliary drainage of gallstones in duodenum to prevent recurrence. Moreover we demonstrated the feasibility of a concomitant percutaneous treatment of biliary disease.