Venous leg ulcer is the most frequent cause of trophic lesions of the limbs in patiens with chronic venous insufficiency. Appropriate management of cutaneous vascular lesions is based on systemic, vascular and local assessment. The Authors used a protease-modulating matrix in 126 patients suffering from venous leg ulcers with wound granulation: 81 (64.2%) patiens with primary chronic reflux disorder and varicose veins and 45 (35.8%) post-thrombotic ; in addition 30 patients (23.8 %) had peripheral arteriopaty and 41 (32.5%) peripheral arteriopaty and diabetes. Onehundred sixteen patients showed complete healing, 2 were refractory to every treatment and 8, with arteriopathy and diabetes, are on the mend. According to the literature we achieved reduction of the healing time and increased healing rate. All patients were treated in outpatient settings. In conclusion the Authors suggest protease-modulating matrix is a really effective treatment of venous leg ulcers with wound granulation. Their treatment is also feasible in outpatient treatment with a reduction in health spending and reduced absence from work.