1 Nov 2007Article
Postoperative follow-up of gastric adenocarcinoma with neoplastic markers and 18-FDG-PET/TC
Alberto Patriti 1Luigina Graziosi 1Nicodemo Baffa 2Eugenio Pacifico 3Papaefthimiou Lamprini 1Saverio Valiani 1Nino Gullà 1Annibale Donini 1
Affiliations
Article Info
1 Università degli Studi di Perugia, Dipartimento di Scienze Chirurgiche, Radiologiche ed Odontostomatologiche. Sezione di Chirurgia Generale e d’Urgenza
2 Azienda Ospedaliera di Perugia, Dipartimento di Diagnostica per Immagini, Servizio PET/TC
3 Azienda Ospedaliera di Perugia, Laboratorio Analisi
Ann. Ital. Chir., 2007, 78(6), 481-485;
Published: 1 Nov 2007
Copyright © 2007 Annali Italiani di Chirurgia
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
INTRODUCTION: The usefulness of tumour markers CEA,CA19.9 and CA72.4 in association with FDG-PET/TC were prospectively evaluated in the post-operative follow-up of gastric cancer patients. MATERIAL AND METHODS: Fifty one consecutive patients were enrolled in a follow-up programme entailing with periodical clinical evaluations, instrumental examinations and tumour markers assay. FDG-PET/TC was performed only in cases of suspected recurrence. RESULTS: Sensitivity of CEA, CA19.9 e CA72.4 during the follow-up period was respectively: 16%,33.3% e 50%. Overall sensitivity was 66.6%. Specificity was 100% for CEA, 93.3% for CA19.9, 100% for CA72.4, with an overall specificity of 96.2%. FDG-PET/TC had a sensitivity of 100%. CONCLUSIONS: Tumour markers in association with FDG-PET/TC allow an early identification of recurrences after surgery, with the advantage to start chemotherapy or surgical protocols before the tumour has reached an advanced stage.
Keywords
- Carcinosis CA19.9
- CA72.4
- CEA
- FDG-PET/TC
- Gastrectomy
- Gastric cancer
- Liver metastasis
- Neoplastic markers
- Recurrence
