AIM OF THE STUDY: The Authors report on two cases of small bowel stromal tumours and underline more recent findings regard to histogenesis, etiopathogenesis and classification as well examine the problems related to diagnosis, surgical management and prognosis of these pathology. CONCLUSIONS: At present, surgical treatment is the best therapy even in patients with local relapse and/or metastasis. Whereas in unresectable patients a new therapeutic possibility is given to the use of Imatinib mesylate, nevertheless is still to prove its effectiveness in regard to survival or as adyuvant treatment in resectable patients with high risk of relapse.