1 Jan 2004Case Report
Cutaneous melanoma with neurofibromatosis type 1: rare association? A case report and review of the literature
P.F. Salvi 1A. Lombardi 1A. Puzzovio 1F. Stagnitti 1M. Tisba 1A. Gaudinieri 2G. Pappalardo 1
Affiliations
Article Info
1 Istituto Dipartimentalizzato di Clinica Chirurgica d’Urgenza e Pronto Soccorso, Università degli Studi di Roma “La Sapienza”
2 Dipartimento di Medicina Sperimentale e Patologia, Università degli Studi di Roma “La Sapienza”
Ann. Ital. Chir., 2004, 75(1), 91-96;
Published: 1 Jan 2004
Copyright © 2004 Annali Italiani di Chirurgia
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
Neurofibromatosis (NF) is a relatively common disorder characterized by cutaneous pigmented maculas, multiple neurofibromas and Lisch nodules (pigmented iris hamartomas). This disorder is retained being a neurocristopathy. Melanocytes are neural crest derivates too. Twenty-six patients with neurofibromatosis associated to cutaneous malignant melanoma have been reported till now, but data on association between these two pathologies are lacking. One more case of malignant cutaneous melanoma in a patient with neurofibromatosis is reported and the hypothesis of a more frequent association than usually believed of these two pathologies is discussed.
Keywords
- Cutaneous melanoma
- Von Recklinghausen’s disease
- neurofibromatosis
- neural crest
