Hepatic fatty infiltration generally appears in a widespread form but it can occasionally involve the liver in an irregular way. As regards focal forms, nodular focal fatty infiltration (NFFI) has great importance regarding problems of differential diagnosis with benign and malignant focal pathology of the liver. Except for this aspect, NFFI has little clinical importance as it is mainly asymptomatic. We report a case of an acute bleeding of a big nodule of FFI which required an urgent hepatectomy.