Background: We have done a prospective, controlled, randomized study to investigate the role of the “zipper”, a new device for skin closure. We have also analysed morbility and advantages with the use of the “zipper” compared with sutures. Methods: 610 consecutive patients underwent surgery for abdominal thoracic endocrinologic and post traumatic pathologies. In 203 cases we used the zipper a new device for skin closure. Results: 6/203 Morbility: in six cases it was necessary to substitute the zipper with sutures or leave the wound healing by second intention. The patients were operated for inguinal hernioplasty, axillarylimphadenectomy,appendicectomy and cholecistectomy. These patients developed complications after surgery as hematoma, lymphorrhea,wound infection and a reintervention. The correction has been done removing the zipper and positioning sutures or leaving the wound healing by second intention. Conclusions: The use of the zipper permits to achieve an efficent seal, a simple application, an aesthetic comfort; it can be applied in local anaesthesia and for its painless, application it is indicated in pediatric surgery.