Background. The prognostic significance of the histological type in gastric cancer is still debated. The correlation between intestinal-diffuse type and tumor recurrence was investigated in a prospective multicentric study which collects the cases from three surgical Departments of Italy. Patients and Metheds. Four-hundred and twelve patients who underwent a potentially curative resection between 1988 and 1995 were considered; 273 cases were classified as intestinal type (group A), and 139 cases as diffuse type (group B). Mixed cases were excluded from the study. All patients were included in a complete follow-up program for the early diagnosis of recurrence. Clinical, histopathological and surgical factors were examined for their influence on tumor recurrence by univariate and multivariate analysis. Results. Recurrence rate was 41.4% in intestinal type, and 65.5% in diffuse type cases (p<0.0001). In group A, multivariate analysis identified nodal status (p<0.0001), depth of invasion (p<0.005), lymph node dis section (D1 vs. D2-D4, p<0.01), advanced age (p<0.01) and male sex (p<0.05) as significant prognostic factors. In group B, depth of invasion (p<0.0005), lymph node dis section (p<0.005), tumor size (p<0.01) and nodal status (p<0.05) resulted as significant variables; no preventive effect on tumor recurrence was found for D2 vs. D1 lymphadenectomy. Multivariate analysis performed on the totality of the cases demonstrated diffuse type as an independent predictor of poor prognosis (relative risk: 1.67, p<0.001). Conclusions. Diffuse type of gastric cancer is an independent risk factor for tumor recurrence as compared with intestinal type; clinical and pathological variables play a different role as prognostic factors in the two histotypes.