Authors report their personal experience about 336 cases of curative surgery for rectal cancer. They describe technical surgical details universally accepted in Letterature such as sharp total mesorectal excision, the extension of limphadenectomy with high ligature of inferior mesenteris artery while pelvic limphadenectomy seems to be unuseful and burdened by high morbidity; finally they under line advantages offered by a colic pouch above all for lower incidence of anastomotic leakages. As adjuvant therapy is concerned, our actual tendency is a preoperative radiochemiotherapy of which we are still eva luating long term results. Finally we analized correlations between cellular genetics and colo-rectal cancer.