AIM: To present a case of scrotal gangrene secondary to Staphylococcus aureus infection, highlighting the importance of early intervention and multidisciplinary care in the management of Fournier's gangrene. CASE PRESENTATION: This case report details the clinical course of a 67-year-old male who presented with severe perineal pain and swelling, later diagnosed as Fournier's gangrene due to Staphylococcus aureus infection. The patient underwent emergency surgical debridement and received antibiotic therapy. Postoperative care included wound cleaning, pain management, and continuous monitoring of clinical and laboratory parameters. RESULTS: The patient showed significant improvement post-surgery, with a marked decrease in white blood cell (WBC) count and C-reactive protein levels, as well as normalization of body temperature. A successful second-stage wound debridement and closure were performed, and the patient experienced no major complications during recovery. The patient reported minimal pain postoperatively and improved daily functioning, contributing to an enhanced quality of life. CONCLUSIONS: This case underscores the critical importance of early aggressive treatment and comprehensive multidisciplinary care in managing Fournier's gangrene. Prompt surgical intervention combined with effective postoperative management can lead to positive outcomes, with significant improvement in clinical and laboratory parameters, enhanced patient comfort, and improved quality of life. Further research is needed to optimize treatment protocols and improve outcomes in similar cases.