Small bowel occlusion by intussusception is not common in adults. It may be due tumor lesion such as melanoma metastase. Bowel melanoma can be a primary lesion or metastases of extra-intestinal melanoma. Primary melanoma, originate in mucosal membranes, is very rare in the bowel, but metastatic melanoma, especially localized in the small bowel, is quite common due of the propensity for cutaneous melanoma to metastasis in the gastrointestinal tract. We present a case of a small bowel obstruction by intussusception in a 58 years old woman with previous history of cutaneous melanoma of the head completely excised; she developed a colic abdominal pain 3 weeks before.