AIM: To report on a case of granular cell tumour occurring in the tongue surgically removed by surgical radiofrequency, with histological examination. MATERIAL OF STUDY: Discussion on the clinico-pathological characteristics of the granular cell tumour and the surgical treatment by surgical radiofrequency: the differential diagnosis is also discussed. RESULTS: Histological examination is mandatory for the final diagnosis. Surgical radiofrequency is an useful medical device to achieve good quality surgery with minimal post-operative course. DISCUSSION CONCLUSIONS: Although rare, granular cell tumour should be always considered in the differential diagnosis of nodular lesions of the oral mucosa above all when the tongue is involved and a yellow appearance is detectable. The surgery will be guided by the clinical diagnosis and accurately performed to prevent recurrence. A medical device promoting reduction of the intra-operative bleeding is suggestable for such surgical treatments.