Association between neuroendocrine tumor of the ileum and two colonic primary malignancies. A case report and review of literature
Luca Napolitano 1, Valentina D’Alessandro 1, Domenico Risio 1, Camilla Marinelli 2, Roberta Cianci 3, Paolo Innocenti 1
Affiliations
Article Info
1 Unit of General and Laparoscopic Surgery, “G. d’Annunzio” University, Chieti, Italy
2 Unit of Pathology, “G. d’Annunzio” University, Chieti, Italy
3 Department of Neurosciences and Imaging, Section of Radiological Imaging, ‘‘G. d’Annunzio’’ University, Chieti, Italy
Abstract
BACKGROUND: A high rate of association between neuroendocrine tumors (NETs) and secondary primary malignancy (SPM) has been described in literature and this association can occur either in a synchronous or a metachronous presentation. A wide range of hypothesis has been postulated to explain the high rate of association between NETs and SPM, without definitive conclusions. CASE PRESENTATION: We report a case of an ileal neuroendocrine tumor found incidentally at the histologic examination of the surgical specimen in a 72 years old male underwent to right hemi colectomy for two colic adenomatous polips with high grade dysplasia. CONCLUSION: Large multicentric epidemiological studies should be considered to assess the association between NETs and SPM.
Keywords
- Neuroendocrine tumors (NETs)
- Progression-Free Survival (PFS)
- Secondary primary malignancy (SPM)