Mycosis fungoides (CTCL) associated with colorectal adenocarcinoma. A rare case of combined response to neoadjuvant therapy
Luciano Grimaldi 1, Roberta Danzi 2, Luigi Sivero 3, Michele Capua 1, Andrea Coppola 1, Roberto Peltrini 1, Massimo Mascolo 4, Michele Danzi 1, Francesco Corcione 1
Affiliations
Article Info
1 Department of Specialized Surgery, Division of General and Oncological Mininvasive Surgery, “Federico II” University, Naples, Italy
2 Department of Radiology and Diagnostic Imaging, “S. Maria delle Grazie” Hospital, Pozzuoli, Naples, Italy
3 Department of Medical-Surgical of the Pathologies of Digestive System, “Federico II” University, Naples, Italy
4 Department of Advanced Biomedical Sciences, Pathology Section, “Federico II” University, Naples, Italy
Abstract
Mycosis fungoides (MF) is a well-known and common form of cutaneous T-cell lymphoma (CTCL), composed of malignant proliferation of CD4+CD45Ro+helper memory T cells. In the patient with MF, the incidence of secondary malignancies is higher than general population but very few cases with both MF and colorectal adenocarcinoma have been reported. Herein we describe a case of MF occurring in a 64-year-old man and followed, five months later, by a diagnosis of colorectal adenocarcinoma. Of notice, simultaneous regression of both rectal mass and cutaneous MF manifestations was observed after administration of chemioradiation therapy prior to rectal surgery. The patient is alive and in stable clinical remission at eight years from the diagnosis.
Keywords
- CTCL
- Colorectal adenocarcinoma
- Mycosis fungoides
- PUVA