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Superior mesenteric artery (SMA) syndrome, also named as Wilkie’s syndrome, is a rare, potentially life-threatening gas-tro-vascular disorder and an uncommon cause of proximal bowel obstruction characterized by a compression of the thirdand final portion of the duodenum by the abdominal aorta and the overlying superior mesenteric artery. There isn’t aconsensus regarding to the optimal treatment of this condition. We describe a case of Wilkie’s syndrome in a young femalewith characteristic symptoms of upper intestinal obstruction, whose diagnosis was delayed for 2 years.