Validity of hepatic resection for cancer in the elderly

Abstract

This retrospective review assessed the safety and validity of elective hepatic resection for cancer in patients ≥65 years of age. Fifty-two patients (31M; 21F; mean age: 70±5 years; range: 65-82) ≥65 years of age underwent hepatic resection for cancer between January 1992 and May 1999). The overall peroperative mortality rate was 8%. The mean hospital stay was 23±10 days (range: 6-45 days), and admission to the intensive care unit was required for only 1 patient. By univariate analysis, preoperative jaundice (p=0.03), length of surgery (≥240 min.) (p=0.006), peroperative blood transfusions (≥500 cc) (p=0.001), and extent of hepatic resection (p=0.01), were predictors of postoperative complications. In a multivariate analysis only peroperative blood transfusions predicted complications (p=0.01). When outcome was compared with that in 65 patients younger than 65 years of age who had hepatic resection for cancer during the same period, there were no difference in terms of morbidity, mortality, and mean hospital stay The 1-, 3-, and 5-year survival rate for patients ≥65 years of age and for patients <65 years of age were 89%, 61%, and 45%, and 87%, 46% and 39% respectively. Hepatic resections can be performed for the elderly with acceptable morbidity and mortality rates and possible long-term survival. Chronological age alone is not a contraindication to liver surgery for malignancies.