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This retrospective review assessed the safety and validity of elective hepatic resection for cancer in patients ≥65 years of age. Fifty-two patients (31M; 21F; mean age: 70±5 years; range: 65-82) ≥65 years of age underwent hepatic resection for cancer between January 1992 and May 1999). The overall peroperative mortality rate was 8%. The mean hospital stay was 23±10 days (range: 6-45 days), and admission to the intensive care unit was required for only 1 patient. By univariate analysis, preoperative jaundice (p=0.03), length of surgery (≥240 min.) (p=0.006), peroperative blood transfusions (≥500 cc) (p=0.001), and extent of hepatic resection (p=0.01), were predictors of postoperative complications. In a multivariate analysis only peroperative blood transfusions predicted complications (p=0.01).