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The attempts to suture wounds with mechanical device are very old, and their history is lost in the night of times. But more recently – that means less than two century ago – already before the true initial beginning of the modern surgery, after the birth of anaesthesiology with the “ether day – 16 october 1846” there have been many efforts to develop new methods to join the tissue of the gut avoiding the danger of peritoneal contamination. The primitive tools of these ancient stapler were founded on the principle to compress with mechanical devices the two sides of the tissue to join.