Rosuvastatin administered intraperitoneally reduces the formation of postoperative adhesions in rats


COD: 01_2018_16_2758 Categorie: ,

S¸tefan Chiorescu, Nicolae Ovidiu Grad, Ion Aurel Mironiuc, Octavian Aurel Andercou

Ann Ital Chir, Digital Edition 2018, 7
Epub Ahead of Print – September 26

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OBJECTIVES: The purpose of the present experimental research was to assess the efficacy of intraperitoneal administration
of rosuvastatin in preventing the formation of postoperative peritoneal adhesions.
MATERIAL AND METHOD: Peritoneal adhesions were induced in 120 male rats of the Wistar-Bratislava breed, divided
into 4 groups (n=30), using a parietal and visceral abrasion model. Group I was designated as the control group; in
the case of group II, a saline solution was administered intraperitoneally, while in the case of groups III and IV, rosuvastatin
solution with a concentration of 10 mg/kg and 5 mg/kg, respectively, was administered in a single dose, during
laparotomy. All rats were sacrificed on the 14th postoperative day and the peritoneal adhesions were assessed macroscopically
and microscopically.
RESULTS: The formation of peritoneal adhesions (assessed macroscopically by appreciating their number, the area covered,
and the degree of severity) was statistically significantly more reduced in the subjects that received rosuvastatin (groups
III and IV) as compared to the control group (p<0.05). The degree of fibrosis assessed microscopically was also statistically significantly reduced in groups III and IV as compared to the control group (p<0.05). CONCLUSIONS: Rosuvastatin administered intraperitoneally correlates with a reduction of peritoneal adhesions in rats.