Role of preoperative sarcopenia in predicting postoperative complications and survival after pancreatoduodenectomy for pancreatic cancer

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Published: Jan 1, 2023
Keywords:
Pancreatic ductal adenocarcinoma, Pancretoduodenectomy, Sarcopenia

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Vincenzo La Vaccara
Department of General Surgery, “La Sapienza” University, Rome, Italy
Chiara Cascone
Department of General Surgery, “La Sapienza” University, Rome, Italy
Alessandro Coppola
Department of General Surgery, “La Sapienza” University, Rome, Italy
Tommaso Farolfi
Department of General Surgery, “La Sapienza” University, Rome, Italy
Roberto Cammarata
Department of General Surgery, “La Sapienza” University, Rome, Italy
Sara Emerenziani
Gastroenterology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy
Roberto Coppola
Department of General Surgery, “La Sapienza” University, Rome, Italy
Damiano Caputo
Department of General Surgery, “La Sapienza” University, Rome, Italy

Abstract

AIM: The aim of this monocentric retrospective study was to investigate the relation between sarcopenia, postoperative complications and survival in patients undergoing radical surgery for pancreatic ductal adenocarcinoma (PDAC).


MATERIAL OF STUDY: From a prospective collected database of 230 consecutive pancreatoduodenectomies (PD), data regarding patient’s body composition, evaluated on diagnostic preoperative CT scans and defined as Skeletal Muscle Index (SMI) and Intramuscular Adipose Tissue Content (IMAC), postoperative complications and long-term outcomes were retrospectively analysed. Descriptive and survival analyses were performed.


RESULTS: Sarcopenia was found in 66% of study population. The majority of patients who developed at least one postoperative complication was sarcopenic. However, sarcopenia did not statistically significantly relate with the development of postoperative complications. However, all pancreatic fistula C occurs in sarcopenic patients. Moreover, there was no significant difference in median Overall Survival (OS) and Disease Free Survival (DFS) between sarcopenic and nonsarcopenic patients (31 versus 31.8 months and 12.9 and 11.1 months respectively).


DISCUSSION: Our results showed that sarcopenia was not related to short- and long-term outcomes in PDAC patients undergoing PD. However, the quantitative and qualitative radiological parameters are probably not enough to study the sarcopenia alone.


CONCLUSIONS: The majority of early stage PDAC patients undergoing PD were sarcopenic. Cancer stage was a determinant factor of sarcopenia while BMI seems less important. In our study, sarcopenia was associated with postoperative complications and in particular with pancreatic fistula. Further studies will need to demonstrated that sarcopenia can be considered an objective measure of patient frailty and strongly associated with short- and long-term outcomes.

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How to Cite
Vincenzo La Vaccara, et al. “Role of Preoperative Sarcopenia in Predicting Postoperative Complications and Survival After pancreatoduodenectomy for Pancreatic Cancer”. Annali Italiani Di Chirurgia, vol. 94, no. 1, Jan. 2023, pp. 45-51, https://annaliitalianidichirurgia.it/index.php/aic/article/view/959.
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Vol. 94 No. 1 (2023)
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Article