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In this article, we reviewed the case of a patient who was object, in 1999, of a published case report of schwannoma
of the jejunal wall. Recently, the patient has been referred to our institution for a mass of the stomach identified by
upper gastrointestinal endoscopy. The patient underwent a wedge resection of the stomach and a histopathological diagnosis
of GIST of the stomach, based on a positive immunohistochemical staining of c-kit and CD34, was made. In
consideration of these findings, we performed immunohistochemistry for c-kit and for CD34 on the previous lesion of
the jejunal wall, which resulted strongly positive for CD117 and negative for CD34. A new diagnosis of gastrointestinal
stromal tumour (GIST) of jejunal wall with moderate risk of progression was made. The lesion was also classified,
according to the AJCC Seventh Edition, as a pT3, pN0, Stage II, GIST. This case shows the importance of a reassessment
of the diagnosis of mesenchymal neoplasm of the small intestine made before the development of anti-CD117 antibody
for a correct prognostic stratification, a better therapeutic management and a close follow-up, if necessary.