Protective effects of ursodeoxycholic acid in experimental corrosive esophagitis injury in rats


COD: 13_2244 Categorie: ,

Adem Küçük, Naci Topalog˘lu, S¸ule Yildirim, Mustafa Tekin, Mesut Erbas,
Hasan Ali Kiraz, Havva Erdem, Aybars Özkan

Ann. Ital. Chir., 2017 88: 82-86

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used for the complications of caustic injuries such as stricture formation. The aim of this study is to establish whether
ursodeoxycholic acid (UDCA) has protective effects on experimental corrosive esophagitis in rats.
Twenty four Wistar-albino rats, weighing 220-240 g, were used in the study. Experimental animals were divided in
three groups randomly: UDCA treatment group (Group T, n:8), control group (Group K, n: 8) and sham group (Group
S, n: 8). In group T and S corrosive esophagitis was induced. UDCA (5 mg/kg) was performed to the group T for 10
days orally. All animals were sacrificed at the end of procedures and histopathological changes in esophageal tissue were
scored by a single investigator who was blind to the groups.
In group T inflammation was present in two rats, muscularis mucosa injury in two rats, grade 1 collagen deposition
in six rats and grade 2 in two rats. In comparison with group S these were statistically significant (p value was 0.003,
0.003 and 0.015, respectively).
UDCA has protective effect in experimental corrosive esophagitis.


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