Propofol: a safe anaesthetic drug in experimental cardiac surgery in rabbits


COD: 01_2018_15_2739 Categorie: ,

Enrico Giuliani, Antonio Manenti, Alberto Barbieri, Alberto Farinetti,
Anna Vittoria Mattioli

Ann. Ital. Chir., 2018 89, 1: 92-94

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BACKGROUND: Experimental surgery needs a pharmacological approach that can interfere with cardiac function.
CASE REPORT: In a animal model of regenerative medicine of myocardium we use an anaesthesiological protocol that
included Propofol, a benzodiazepine (Midazolam) and an alpha-2 adrenergic agent.
RESULTS: In a group of 15 rabbits undergoing cardiac surgery we reported 1 arrhythmic complication during stem cell
DISCUSSION: The functional cardio- respiratory depressor activity of Propofol was compensated by alpha-2 adrenergic
drugs, avoiding serious complications. We hypothesize that the functional cardio-respiratory depressor of different anaesthesiological
drugs can be reversed by the contemporary administration of with adrenergic agents.