Propofol: a safe anaesthetic drug in experimental cardiac surgery in rabbits

Article Sidebar

PDF
Published: Jan 1, 2018
Keywords:
Arrhythmias, Cardiac ischemia, Cardiovascular toxicity, Propofol

Main Article Content

Enrico Giuliani
University of Modena and Reggio Emilia, Italy; Department of Medical and Surgical Sciences
Antonio Manenti
University of Modena and Reggio Emilia, Italy; Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine
Alberto Barbieri
University of Modena and Reggio Emilia, Italy; Department of Medical and Surgical Sciences
Alberto Farinetti
University of Modena and Reggio Emilia, Italy; Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine
Anna Vittoria Mattioli
University of Modena and Reggio Emilia, Italy; Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine

Abstract





ACKGROUND: Experimental surgery needs a pharmacological approach that can interfere with cardiac function.


CASE REPORT: In a animal model of regenerative medicine of myocardium we use an anaesthesiological protocol that included Propofol, a benzodiazepine (Midazolam) and an alpha-2 adrenergic agent.


RESULTS: In a group of 15 rabbits undergoing cardiac surgery we reported 1 arrhythmic complication during stem cell injection.


DISCUSSION: The functional cardio- respiratory depressor activity of Propofol was compensated by alpha-2 adrenergic drugs, avoiding serious complications. We hypothesize that the functional cardio-respiratory depressor of different anaes- thesiological drugs can be reversed by the contemporary administration of with adrenergic agents.





Article Details

How to Cite
Enrico Giuliani, et al. “Propofol: A Safe Anaesthetic Drug in Experimental Cardiac Surgery in Rabbits”. Annali Italiani Di Chirurgia, vol. 89, no. 1, Jan. 2018, pp. 92-94, https://annaliitalianidichirurgia.it/index.php/aic/article/view/1061.
Issue
Vol. 89 No. 1 (2018)
Section
Case Report