Problematiche immunologiche degli omoinnesti vascolari

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M. D’ADDATO, M. MIRELLI

Ann. Ital. Chir., LXXII, 2, 2001

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Fresh arterial homografts are immunogenic, inducing in
recipient a strong immune response specifically directed against
the antigens of the donor graft. The initial immune response
seems to be cellular (lymphocytotoxic) and the late reaction
humoral (antibody), even if they are stricty correlated.
Immunosuppressive therapy reduce the immune reaction, but
this response is dose-related.
Implanted arterial homografts induce a donor-specific
response similar to chronic reaction, which occurs in the
recipients of vascularized solid-organ allografts. Therefore, in
arterial transplantation, ABO compatibility and negative
crossmatch should be respected.
Effort should be made to curb the immune response by
prospective cross-matching, immunosuppressive therapy and
preoperative manipulation of homografts to reduce their
antigenicity.

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