CURRENT TRENDS AND STRATEGIES IN THE TREATMENT OF BREAST CANCER

Abstract

Carcinoma of the breast is a pathology of great social inte rest for its increase in occurrence and because it is leading cause of tumor-induced death among women in Western Countries.

There have been continual changes in the understanding of biological implications of the tumor and in the ensuing the rapeutic approaches. Breast cancer is currently viewed as a systemic disorder right from is outset varies widely in beha vior within the same histologic type. Hence, the need for a multidisciplinary approach where locoregional treatment (surgery and radiotherapy) is accompanied by systemic (che motherapy and hormone therapy). As to surgery, there as been a shirt away from the radical to the conservative approach which avoids functional and above all psycholo gical mutilation. Beside always being carried out when sur gery is not radical, radiotherapy depends on the stage of the tumor. As to chemotherapy, while there is sound evidence proving it to be useful in postoperative adjuvant treatment, its usefulness in preoperative treatment still remains to be demonstrated. Future studies will have to identify new morphobiological parameters of the tumor capable of pre dicting the clinical behavior and response to therapy of the various types of breast cancer so as to correctly standardize therapeutic actions and their aiming.