Neuroendocrine tumors of the urinary bladder. A case series and review of the literature

Abstract

Neuroendocrine carcinoma cases, more frequent in the GI tract, have rarely been reported in extrapulmonary areas. Neuroendocrine carcinoma of the bladder is one of the malignancies with a poor prognosis, which is expected to cause rapid metastases. In addition, neuroendocrine carcinoma of the bladder constitutes < 1% of all bladder carcinomas. In this study, we present two rare cases, a combined small cell neuroendocrine carcinoma–high-grade urothelial carcinoma and a large cell neuroendocrine carcinoma, diagnosed at Çanakkale Onsekiz Mart University, Research and Practice Hospital Pathology Clinic, between November 2016 and January 2017.