Mycosis fungoides (CTCL) associated with colorectal adenocarcinoma. A rare case of combined response to neoadjuvant therapy


COD: 26_03_2021_3526_ep Categorie: , ,

Luciano Grimaldi, Roberta Danzi, Luigi Sivero, Michele De Capua, Andrea Coppola, Roberto Peltrini, Massimo Mascolo, Michele Danzi, Francesco Corcione

Ann Ital Chir, 2021; 10 – Mar. 26
Online Epub

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Mycosis fungoides (MF) is a well-known and common form of cutaneous T-cell lymphoma (CTCL), composed of malignant proliferation of CD4+CD45Ro+helper memory T cells. In the patient with MF, the incidence of secondary malignancies is higher than general population but very few cases with both MF and colorectal adenocarcinoma have been reported.
Herein we describe a case of MF occurring in a 64-year-old man and followed, five months later, by a diagnosis of colorectal adenocarcinoma. Of notice, simultaneous regression of both rectal mass and cutaneous MF manifestations was observed after administration of chemioradiation therapy prior to rectal surgery. The patient is alive and in stable clinical remission at eight years from the diagnosis.