Multiple endocrine neoplasia type 2A syndrome (MEN2A) and usefulness of 68Ga-DOTATATE PET/CT in this syndrome.

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COD: 3012_04_03_2019_AOP Categorie: ,

Şadiye Altun Tuzcu, Zafer Pekkolay

Ann Ital Chir, Digital Edition 2019; 8
Epub Ahead of Print – March 4

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AIM: The aim of this study was to evaluate a new imaging method 68Ga-DOTATATE PET/CT as an alternative
method to diagnose evidence of neuroendocrine tumors or their metastasis (if any) in patient with MEN 2A.
METHODS: Three patients( 2F, 1M; age 28,46 and 50 years) with MEN 2A syndrome who underwent 68Ga-DOTATATE
PET/CT scan were prospectively evaluated. PET/CT images were analyzed with measurement of maximum standardized
uptake value (SUVmax).
RESULTS: All patients had adrenal masses with increased uptake of 68Ga-DOTATATE (first case adrenal mass SUVmax:
9,1, second case adrenal mass SUVmax: 32,4(right), 30,3(left) and third case SUVmax:12,4). All of the patients had
medullary thyroid carcinoma with increased uptake of 68Ga-DOTATATE (first case SUVmax: 3,3 second case
SUVmax:7,7 and third case SUVmax: left thyroid nodule: 19,4, right thyroid nodule: 21,2). Third case has a parathyroid
adenoma with SUVmax: 2,8.
CONCLUSIONS: New imaging method 68Ga-DOTATATE PET/CT may be an alternative method to diagnose MEN 2A
patients. 68Ga-DOTATATE PET/CT can give a great opportunity to detecting the multiple neoplasia like MEN 2A
with only one session.

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