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In order to investigate new therapeutic strategies for hepatocellular carcinoma (HCC), an animal model easily reproducible of hepatic tumor is necessary. Several techniques of intrahepatic tumor implantation have been reported in the literature. Many of them have the disadvantage of high rate of artificial neoplastic extrahepatic dissemination, both peritoneal and systemic. These drawbacks interfere with the eva – luation of treatment efficacy. In this study we describe a modified technique of intrahepatic tumor implantation in the rat, previously reported by Yang in 1992, which is based on the insertion in the liver, after neoplastic tissue, of a piece of hemostatic sponge (Spongostan®) that permits to significantly reduce the rate of artificial neoplastic dissemination.