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Skeletal metastasis by pancreatic adenocarcinoma are infrequent, and those located in the craniofacial region are very
rare. We report the case of a 63-year-old Caucasian woman with a metastatic adenocarcinoma of the pancreatic head
previously treated with surgery and chemotherapy presenting a skeletal metastasis in the left cheekbone 5 years after primary
treatment. No other similar cases have been previously described. The therapeutic decision was not simple because
of the uncommon site of pancreatic metastasis. Surgical resection was the only possibility after the radiotherapy failure.