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BACKGROUND: Merkel cell carcinoma (MCC) is a rare and aggressive skin tumour with a highly malignant nature whose
appropriate treatment is still debated. The Authors report a case of cutaneous metastasis from neuroendocrine carcinoma
and analyse new diagnostic and terapeutic options of neoplasms that occurs in sun-exposed areas.
METHODS: The authors present the clinical, immunocytochemical characteristic of primary and secondary skin localization
of a neuroendocrine tumor that affected a woman.
RESULTS: Histological and immunocytochemical analysis demonstrated that the secondary cutaneous localization appeared
to be compared to the primary tumour.
CONCLUSIONS: The case confirm the high incidence of regional metastasis; a wide surgical excision of tumor and regional
lymphadenectomy is therefore recommended for primary treatment of MCC; the radiation treatment minimized the
local recidives with long time survival.