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Castleman’s disease (CD) was described from Benjamin Castleman in 1954. The disease today is enumerated among lymphoproliferative disorders and has unknown etiology, but a interleukin-6 (IL- 6) dysregulation and a reaction to viral antigens (HHV8) especially in patients with immunodeficiency is suspected. It is observed in adult and young people, in male or female with equal frequency; the appearance in childhood is extremely rare. The disease shows various clinical and histological pictures, with a localized type (involvement of one lymph node group) described more frequently than the multicentric one. Histological examination distinguish a “hyaline-vascular type” that represents approximately the 91%, a “plasma cell type” that represents approximately the 9% has an aggressive clinical outcome, and the “ mixed types”. Initial symptoms are nearly absent, but not for the plasma cell type.