Jaw bones regeneration using mesenchymal stem cells. A single-center experience

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Published: Jan 1, 2018
Keywords:
Bone regeneration, Mesenchymal stem cells, BM-MSC, Upper jaw, Mandible

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Walter Colangeli
Department of Clinical and Experimental Medicine, Maxillofacial Surgery Unit (Head: Prof. M.o Giudice), University of Magna Graecia, Catanzaro, Italy
Umberto Riccelli
Department of Clinical and Experimental Medicine, Maxillofacial Surgery Unit (Head: Prof. M.o Giudice), University of Magna Graecia, Catanzaro, Italy
Amerigo Giudice
Department of Clinical and Experimental Medicine, Maxillofacial Surgery Unit (Head: Prof. M.o Giudice), University of Magna Graecia, Catanzaro, Italy
Ida Barca
Department of Clinical and Experimental Medicine, Maxillofacial Surgery Unit (Head: Prof. M.o Giudice), University of Magna Graecia, Catanzaro, Italy
Davide Caruso
Department of Clinical and Experimental Medicine, Maxillofacial Surgery Unit (Head: Prof. M.o Giudice), University of Magna Graecia, Catanzaro, Italy
Daniela Novembre
Department of Clinical and Experimental Medicine, Maxillofacial Surgery Unit (Head: Prof. M.o Giudice), University of Magna Graecia, Catanzaro, Italy
Claudio Tortosa
Department of Clinical and Experimental Medicine, Maxillofacial Surgery Unit (Head: Prof. M.o Giudice), University of Magna Graecia, Catanzaro, Italy
Raffaella Cordaro
Department of Clinical and Experimental Medicine, Maxillofacial Surgery Unit (Head: Prof. M.o Giudice), University of Magna Graecia, Catanzaro, Italy
Maria Giulia Cristofaro
Department of Clinical and Experimental Medicine, Maxillofacial Surgery Unit (Head: Prof. M.o Giudice), University of Magna Graecia, Catanzaro, Italy

Abstract





PURPOSE: Mesenchymal stem cells (MSC), which are multipotent stromal cells, are considered to be a promising resource in tissue engineering and tissue regeneration. MSCs have been used to generate new maxillary bone with clinically suc- cessful results. The aim of this study was to determine the role of MSC in bone regeneration procedures in patients with benign maxillary lesions.


METHODS: A study was conducted on five patients treated for maxillary bone defects resulting from biopsy of benign lesions at the University Hospital of Magna Græcia, Catanzaro, Italy from January 2015 to October 2016. MSC from autologous bone marrow were used for bone regeneration. The bone mineral density was compared, using the Hounsfield scale, before and after treatment. Follow-up was monthly for six months, and the patients underwent a computed tomog- raphy scan of the maxilla at 6 months.


RESULTS: Five patients, who underwent biopsy of osteolytic odontogenic benign tumors, were included in the study. There were no intraoperative or postoperative complications. The mean volume of the newly formed bone was 2.44cm3 (range 2,0-3,1) and the mean bone density was 1137 Hounsfield Units (range 898-1355).
CONCLUSIONS: Bone regeneration with MSC from autologous bone marrow appears to be a valid treatment option for maxillary bone defects.





Article Details

How to Cite
Walter Colangeli, et al. “Jaw Bones Regeneration Using Mesenchymal Stem Cells. A Single-Center Experience”. Annali Italiani Di Chirurgia, vol. 89, no. 1, Jan. 2018, pp. 20-23, https://annaliitalianidichirurgia.it/index.php/aic/article/view/977.
Issue
Vol. 89 No. 1 (2018)
Section
Review