Jaw bones regeneration using mesenchymal stem cells.


COD: 01_2018_02_2789 Categorie: ,

Walter Colangeli, Umberto Riccelli, Amerigo Giudice, Ida Barca, Davide Caruso,
Daniela Novembre, Claudio Tortosa, Raffaella Cordaro, Maria Giulia Cristofaro

Ann Ital Chir, Digital Edition 2018, 7
Epub, December 21

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PURPOSE: Mesenchymal stem cells (MSC), which are multipotent stromal cells, are considered to be a promising resource
in tissue engineering and tissue regeneration. MSCs have been used to generate new maxillary bone with clinically successful
results. The aim of this study was to determine the role of MSC in bone regeneration procedures in patients with
benign maxillary lesions.
METHODS: A study was conducted on five patients treated for maxillary bone defects resulting from biopsy of benign
lesions at the University Hospital of Magna Græcia, Catanzaro, Italy from January 2015 to October 2016. MSC from
autologous bone marrow were used for bone regeneration. The bone mineral density was compared, using the Hounsfield
scale, before and after treatment. Follow-up was monthly for six months, and the patients underwent a computed tomography
scan of the maxilla at 6 months.
RESULTS: Five patients, who underwent biopsy of osteolytic odontogenic benign tumors, were included in the study. There
were no intraoperative or postoperative complications. The mean volume of the newly formed bone was 2.44cm3 (range
2,0-3,1) and the mean bone density was 1137 Hounsfield Units (range 898-1355).
CONCLUSIONS: Bone regeneration with MSC from autologous bone marrow appears to be a valid treatment option for
maxillary bone defects.