Is there an association between Helicobacter Pylori cytotoxin Cag A seropositivity and risk for gastric cancer?


COD: 2002_06_571-578 Categorie: ,

G.L. Baiocchi, N. Vettoretto, D. Colombrita, M. Giovanetti, A. Coniglio, S. Bonardelli, A. Pelizzari, M. Ronconi, G.A.M. Tiberio, S.M. Giulini

Ann. Ital. Chir., LXXIII, 6, 2002

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Background: Since discovered in 1990, Cag A, a protein expressed by specific strains of Helicobacter pylori, was thought able to explain why only a few Helicobacter infected patients develop peptic diseases and gastric cancer. However, clinical trials provide discordant results. Materials and Methods: In this study we evaluate Helicobacter pylori and Cag A seropositivity in 35 cancer affected patients, in 36 gastritis affected patients and in 40 healthy blood donors by means of two comercially available fluorescence enzyme-immunoessay (ELISA). Results: Odds ratios determination strongly suggests that Cag A bearer Helicobacter strains play a pathogenetic role in gastric diseases (OR 4.23, 95% CI 3.22-5.24 for cancer versus healthy volounteers, OR 3.2, 95% CI 2.19-4.21 for gastritis versus asymptomatic patients), but is unable to demonstrate a direct carcinogenic activity (cancer-gastritis difference is not significant: OR 1.32, 95% CI 0.39-1.25).


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