Ali Inal
Dicle University, Department of Medical Oncology, Diyarbakir, Turkey
Tulay Akman
Dokuz Eylül University, Department of Medical Oncology, izmir, Turkey
Sebnem Yaman
Department of Medical Oncology, Ankara Numune Education and Research Hospital, Ankara, Turkey
Selcuk Cemil Ozturk
Gazi University, Department of Medical Oncology, Ankara, Turkey
Caglayan Geredeli
Secuk University, Meram Medical Faculty, Konya, Turkey
Mehmet Bilici
Ataturk University, Department of Medical Oncology, Erzurum, Turkey
Mevlude Inanc
Erciyes University, Department of Medical Oncology, Kayseri, Turkey
Hakan Harputoglu
Inonu University, Department of Medical Oncology, Malatya, Turkey
Umut Demirci
Ataturk Education and Research Hospital, Ankara, Turkey
Ali Suner
Gaziantep University, Department of Medical Oncology, Gaziantep, Turkey
Havva Yesil Cınkır
Dr. Abdurrahman Yurtaslan Education and Research Hospital, 2. Department of Medical Oncology, Ankara, Turkey
Suleyman Alıcı
Goztepe Medikal Park Hospital, stanbul, Turkey
Dilsen Colak
Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey
Ozlem Uysal Sonmez
Dr. Abdurrahman Yurtaslan Education and Research Hospital, 1. Department of Medical Oncology, Ankara, Turkey
Gamze Goksel
Celal Bayar University, Department of Medical Oncology, Manisa, Turkey
Gamze Gokoz Dogu
Pamukkale University School of Medicine, Department of Medical Oncology, denizli, Turkey
Huseyin Engin
Zonguldak Karaelmas University School of Medicine, Department of Medical Oncology, Zonguldak
Olcun Umit Unal
Dokuz Eylül University, Department of Medical Oncology, izmir, Turkey
Tulay Tamozlu
Department of Medical Oncology, Ankara Numune Education and Research Hospital, Ankara, Turkey
Suleyman Buyukberber
Gazi University, Department of Medical Oncology, Ankara, Turkey
Cem Melih Boruban
Secuk University, Meram Medical Faculty, Konya, Turkey
Abdurrahman Isıkdogan
Dicle University, Department of Medical Oncology, Diyarbakir, Turkey
Abstract
Several studies have now demonstrated that the lymph node ratio (LNR), as a superior indicator of axillary tumor burden to the number of excised nodes. While, about the prognostic value of LNR on the the survival of elderly patients is limited. The aim of this retrospective multicenter study is to evaluate the prognostic value of lymph node ratio in elderly patients with node positive breast cancer.
METHODS: Onehundredeightyfour patient with operable breast cancer, recruited from 17 institutions, were enrolled into the retrospectively study. Eleven potential prognostic variables were chosen for analysis in this study. Univariate and multivariate analyses were conducted to identify prognostic factors associated with survival.
RESULT: Among the eleven variables of univariate analysis, four variables were identified to have prognostic significance for Overall survival (OS): pathologic tumor size (T), No. of positive nodes (N), LNR and estrogen receptor-positive (ER). Among the eleven variables of univariate analysis, two variables were identified to have prognostic significance for Disease-free survival (DFS): N and LNR. Multivariate analysis by Cox proportional hazard model showed that T, LNR and ER were considered independent prognostic factors for OS. Furthermore, LNR was considered independent prognostic factors for DFS.
CONCLUSION: In conclusion, the LNR was associated with the prognostic importance for DFS and OS in elderly patients who were administered adjuvant treatments.