Is lymph node ratio prognostic factor for survival in elderly patients with node positive breast cancer? The Anatolian Society of Medical Oncology

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Ali Inal
Tulay Akman
Sebnem Yaman
Selcuk Cemil Ozturk
Caglayan Geredeli
Mehmet Bilici
Mevlude Inanc
Hakan Harputoglu
Umut Demirci
Ali Suner
Havva Yesil Cınkır
Suleyman Alıcı
Dilsen Colak
Ozlem Uysal Sonmez
Gamze Goksel
Gamze Gokoz Dogu
Huseyin Engin
Olcun Umit Unal
Tulay Tamozlu
Suleyman Buyukberber
Cem Melih Boruban
Abdurrahman Isıkdogan

Abstract

Several studies have now demonstrated that the lymph node ratio (LNR), as a superior indicator of axillary tumor burden to the number of excised nodes. While, about the prognostic value of LNR on the the survival of elderly patients is limited. The aim of this retrospective multicenter study is to evaluate the prognostic value of lymph node ratio in elderly patients with node positive breast cancer.


METHODS: Onehundredeightyfour patient with operable breast cancer, recruited from 17 institutions, were enrolled into the retrospectively study. Eleven potential prognostic variables were chosen for analysis in this study. Univariate and multivariate analyses were conducted to identify prognostic factors associated with survival.


RESULT: Among the eleven variables of univariate analysis, four variables were identified to have prognostic significance for Overall survival (OS): pathologic tumor size (T), No. of positive nodes (N), LNR and estrogen receptor-positive (ER). Among the eleven variables of univariate analysis, two variables were identified to have prognostic significance for Disease-free survival (DFS): N and LNR. Multivariate analysis by Cox proportional hazard model showed that T, LNR and ER were considered independent prognostic factors for OS. Furthermore, LNR was considered independent prognostic factors for DFS.


CONCLUSION: In conclusion, the LNR was associated with the prognostic importance for DFS and OS in elderly patients who were administered adjuvant treatments.

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How to Cite
Inal, Ali, et al. “Is Lymph Node Ratio Prognostic Factor for Survival in Elderly Patients With Node Positive Breast Cancer? The Anatolian Society of Medical Oncology”. Annali Italiani Di Chirurgia, vol. 84, no. 2, Mar. 2013, pp. 143-8, https://annaliitalianidichirurgia.it/index.php/aic/article/view/1525.
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