Influenza del tipo istologico sulla prognosi dei pazienti sottoposti ad intervento curativo per adenocarcinoma gastrico. Studio multicentrico italiano

25.00

G. DE MANZONI, F. ROVIELLO, D. MARRELLI, P. MORGAGNI, A. DI LEO*, L. SARAGONI, A. DE STEFANO, F. BAZZOCCHI, E. PINTO

Ann. Ital. Chir., LXXII, 1, 2001

La mia nuova descrizione qui!

Price of a print issue €25.00

Background. The prognostic significance of the histological
type in gastric cancer is still debated. The correlation
between intestinal-diffuse type and tumor recurrence was
investigated in a prospective multicentric study which col –
lects the cases from three surgical Departments of Italy.
Patients and Metheds. Four-hundred and twelve patients
who underwent a potentially curative resection between
1988 and 1995 were considered; 273 cases were classified
as intestinal type (group A), and 139 cases as diffuse type
(group B). Mixed cases were excluded from the study. All
patients were included in a complete follow-up program for
the early diagnosis of recurrence. Clinical, histopathological
and surgical factors were examined for their influence on
tumor recurrence by univariate and multivariate analysis.
Results. Recurrence rate was 41.4% in intestinal type, and
65.5% in diffuse type cases (p<0.0001). In group A, multivariate analysis identified nodal status (p<0.0001), depth of invasion (p<0.005), lymph node dis - section (D1 vs. D2-D4, p<0.01), advanced age (p<0.01) and male sex (p<0.05) as significant prognostic factors. In group B, depth of invasion (p<0.0005), lymph node dis - section (p<0.005), tumor size (p<0.01) and nodal status (p<0.05) resulted as significant variables; no preventive effect on tumor recurrence was found for D2 vs. D1 lymphadenectomy. Multivariate analysis performed on the totality of the cases demonstrated diffuse type as an inde - pendent predictor of poor prognosis (relative risk: 1.67, p<0.001). Conclusions. Diffuse type of gastric cancer is an indepen - dent risk factor for tumor recurrence as compared with inte - stinal type; clinical and pathological variables play a dif - ferent role as prognostic factors in the two histotypes.

0

Utilizzando il sito, accetti l'utilizzo dei cookie da parte nostra. maggiori informazioni

Questo sito utilizza i cookie per fornire la migliore esperienza di navigazione possibile. Continuando a utilizzare questo sito senza modificare le impostazioni dei cookie o cliccando su "Accetta" permetti il loro utilizzo.

Chiudi