Il trattamento dei tumori stromali gastrici (GIST). Revisione della letteratura e descrizione di caso clinico


Girolamo Geraci, Francesco Li Volsi, Franco Pisello, Carmelo Sciumè, Massimo Cajozzo, Calogero Cavaleri, Giuseppe Modica

Ann. Ital. Chir., 2005; 76: 377-381

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BACKGROUND: Gastrointestinal stromal tumors (GIST) are rare mesenchimal tumors that are characterized by constitutive
overexpression of the tyrosin-kinase receptor KIT (CD117). The authors analyse the basis of the treatment of gastric
GIS, starting form the study of a recent observed case.
EXPERIMENTAL DESIGN: Report of one case treated with endoscopic resection. Evaluation of treatment and 2-years followup.
RESULTS: The treatment of gastric GIST must be modulated on prognostic, genetic and molecular factors. These factors
are the basis of the formation and growth of GIST.
CONCLUSIONS: Complete surgical extirpation without rupture remains the only curative treatment of localized favourable
prognosis. Endoscopic treatment, as in our case, reflect the modulation of therapy on prognostic factors. Selective targeted
therapy of metastatic disease yields encouraging clinical responses.