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Young age is believed to be a risk factor for hereditary or familial non-polyposis colorectal cancer. Pr esent study analysed frequency, phenotype and familial cancer risk of 82 subjects with colorectal cancer under 55 years of age. According to age and family history, probands have been subdivided into 5 groups:
– Hereditary Non-Polyposis Colorectal Cancer (HNPCC)
(8.2% of cases);
– Suspected HNPCC (7.3%);
– Non-specific familial aggregation of colorectal cancer
– Early-onset colorectal cancer (diagnosis under 35 years of
age) (CCG) (6.1%);
– Sporadic colorectal cancer (CCS) (58.5%).
Proportions of probands with multiple colonic tumours were highest in HNPCC (57.1%), but present in AFACC (12.5%) and CCG (20.0%) groups, as well. Extracolonic, in particular endometrial and ovarian cancers have been found in HNPCC and AFACC probands. Tumours of proximal colon were most frequent in HNPCC, suspected HNPCC, CCG patients. Eleven-years survival rate was higher in HNPCC probands then in CCS group. Familial cancer risk in HNPCC was 3 times as much as in CCG + CCS groups.