Human donor decellularized dermal matrix produced by a skin bank A new treatment for abdominal wall defects

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COD: 2716_25_07_2017_AOP Categorie: ,

Martina Ghetti, Elena Bondioli, Valeria Purpura, Giovanna Cenacchi,
Paolo Ruscelli, Davide Melandri

Ann Ital Chir, Digital Edition 2017; 6
Epub Ahead of Print – July 25

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BACKGROUND: Interest is increasing for human decellularized scaffolds for their ability to favor healing and cell infiltration
after transplantation, in the treatment of abdominal wall defects. The purpose of the present study is to show
the clinical results obtained after the application of human decellularized dermal matrix (HDM) produced by RER Skin
Bank, on patients suffering from different abdominal wall defects.
METHODS: Between 2012 and 2014, 64 patients, average age 64 years, received HDM, to replace and cover the damage
area during abdominal wall surgery. After surgical procedures, all patients were followed weekly for the first month
and then monthly up to 6 months postoperative and any major problem or complication were recorded. Six months
follow up included abdominal exams, serological tests and MRI analysis in order to evaluate integration of HDM with
the patient’s surroundings tissues and eventual long-term complications.
RESULTS: Incisional hernia was the most frequent clinical condition in which HDM was applied, requiring also the
highest amount of human decellularized dermal matrix. One month after the surgical operation, 61 patients revealed a
well tolerability of HDM and a normal wound healing was also identified in all the damage areas. Only 3 patients
experienced postoperative infections. Moreover the follow up after 6 months reported no signs of dermis rejection and
that none of the patients was positive to serological tests.
CONCLUSIONS: Human decellularized dermal matrix can be considered a safe and useful bioproduct to treat large abdominal
defects, characterized by minor complications and simplicity to be implanted.

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