Helicobater Pylori e Carcinoma Gastrico

25.00

A. ARMUZZI, A. GASBARRINI, M. GABRIELLI, F. CREMONINI, M. ANTI, G. GASBARRINI

Ann. Ital. Chir., LXXII, 1, 2001

La mia nuova descrizione qui!

Price of a print issue €25.00

Among the suspected bacterial causes of cancer, H. pylori is the agent more consistently linked to malignancy. After its discovery in 1983 and the later confirmation as the leading cause of chronic gastritis, several studies were performed to prove an association between H. pylori infection and gastric carcinoma. The epidemiological data have been so strong that in 1994 the International Association for Research on Cancer stated that “there was sufficient evidence” to classify H. pylori as a group I carcinogen in humans. However, the exact mechanisms underlying the link between H. pylori infection and gastric carcinoma remain still to be elucidated. Thenatural history of H. pylori infection shows that, although roughly half of the world’s human population bears the organism, only a minority of individuals develop clinically important outcomes (e.g. peptic ulcer, lymphoproliferative diseases, atrophic gastritis and gastric carcinoma): host’s genetic make-up, duration of infection, diet and differences between H. pylori strains have been proposed as factors potentially able to influence the outcomes in different bindividuals.