Good results of surgery for renal cell carcinoma depend on early diagnosis. The need for an extensive screening program

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COD: 08_1211_2450 Categorie: ,

Enrico Fiori, Alessandro De Cesare, Daniele Crocetti, Daniele Ferraro, Cecilia Barmann, Antonio V. Sterpetti, Giorgio De Toma

Ann. Ital. Chir., 2016 87: 41-44

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Good results of surgery for renal cell carcinoma depend on early diagnosis. The needs for an extensive screening
program
AIM: The aim of our study was to assess the value of several prognostic factors for patients with clear cell renal carcinoma
without distant metastases (M0) who underwent surgery in our Department from 1980 to 2010.
MATERIAL OF STUDY: We analyzed131 consecutive patients with clear cell renal carcinoma who had nephrectomy and
extended lymph node dissection from 1980 to 2010 were reviewed. Free from cancer survivals were correlated to several
prognostic factors including preoperative blood cell count, tumour cellular differentiation and stage of the disease.
RESULTS: In our study we confirmed the importance of the stage of the tumour, in particular of the T, as prognostic
factor. Survival was strictly correlated to the stage of the disease: 10 year cancer free survival was 100% in patients
with T1, 83% in patients with T2 N0 and 34% for patients with T3N0. No improvement of results was noted in
the last years, due to unchanged proportion of early diagnosis.
DISCUSSION: Long term survival after surgery for clear cell renal carcinoma depends mainly on the histology type of the
tumour and on the stage of the disease. Renal carcinoma does not respond to radio and standard chemotherapy and
surgery represents the only effective cure.
CONCLUSION: Surgery at earlier stages is essential to improve results in patients with renal carcinoma. Earlier diagnosis
at the present time is the best possibility to improve results, with the need for extensive use of screening ultrasound test.

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